Cadmium association with DREAM promotes DREAM interactions with intracellular partners in a similar manner to its physiological ligand, calcium.

Azam S, Miksovska J.

Metallomics 2019: doi: 10.1039/c9mt00059c. [Epub ahead of print] 

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Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an N-Unsubstituted 1,2,3-Triazol-4-yl Moiety.

Wen Z, Tuttle PR, Howlader AH, Vasilyeva A, Gonzalez L, Tangar A, Lei R, Laverde EE, Liu Y, Miksovska J, Wnuk SF.

J Org Chem. 2019; 84(6):3624-3631

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Utility of fluorescent heme analogue ZnPPIX to monitor conformational heterogeneity in vertebrate hexa-coordinated globins.

Tangar A, Derrien V, Lei R, Santiago Estevez MJ, Sebban P, Bernad S, Miksovska J.

Metallomics. 2019 doi: 10.1039/c8mt00332g. [Epub ahead of print]

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The effects of solution additives and gas-phase modifiers on the molecular environment and conformational space of common heme proteins.

Butcher D, Miksovska J, Ridgeway ME, Park MA, Fernandez-Lima F.

Rapid Commun Mass Spectrom. 2018 Nov 13. doi: 10.1002/rcm.8347. 

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Pb2+ Binds to Downstream Regulatory Element Antagonist Modulator (DREAM) and Modulates Its Interactions with Binding Partners: A Link between Neuronal Calcium Sensors and Pb2+ Neurotoxicity.

Azam S, Miksovska J.

ACS Chem Neurosci. 2018 Nov 21. doi: 10.1021/acschemneuro.8b00335. 

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β-Cyclodextrin Reverses Binding of Perfluorooctanoic Acid to Human Serum Albumin.

Weiss-Errico MJ, Miksovska J, O'Shea KE.

Chem Res Toxicol. 2018 Apr 16;31(4):277-284. doi: 10.1021/acs.chemrestox.8b00002.

 

Insights from ion mobility-mass spectrometry, infrared spectroscopy, and molecular dynamics simulations on nicotinamide adenine dinucleotide structural dynamics: NAD+vs. NADH.

Molano-Arevalo JC, Gonzalez W, Jeanne Dit Fouque K, Miksovska J, Maitre P, Fernandez-Lima F.

Phys Chem Chem Phys. 2018 Mar 7;20(10):7043-7052. doi: 10.1039/c7cp05602h.

 

Characterization of Intramolecular Interactions of Cytochrome c Using Hydrogen-Deuterium Exchange-Trapped Ion Mobility Spectrometry-Mass Spectrometry and Molecular Dynamics.

Molano-Arevalo JC, Jeanne Dit Fouque K, Pham K, Miksovska J, Ridgeway ME, Park MA, Fernandez-Lima F.

Anal Chem. 2017 Sep 5;89(17):8757-8765. doi: 10.1021/acs.analchem.7b00844. 

 

Synthesis of 8-(1,2,3-triazol-1-yl)-7-deazapurine nucleosides by azide-alkyne click reactions and direct C-H bond functionalization.

Kavoosi S, Rayala R, Walsh B, Barrios M, Gonzalez WG, Miksovska J, Mathivathanan L, Raptis RG, Wnuk SF.

Tetrahedron Lett. 2016 Sep 28;57(39):4364-4367.

 

Role of Ionic Strength and pH in Modulating Thermodynamic Profiles Associated with CO Escape from Rice Nonsymbiotic Hemoglobin 1.

Butcher D, Bernad S, Derrien V, Sebban P, Miksovska J.

J Phys Chem B. 2017 Jan 19;121(2):351-364. doi: 10.1021/acs.jpcb.6b06933.

 

Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases.

Gu M, Berrido A, Gonzalez WG, Miksovska J, Chambers JW, Leng F.

Sci Rep. 2016 Oct 31;6:36006. doi: 10.1038/srep36006.

 

Structures of the kinetically trapped i-motif DNA intermediates.

Garabedian A, Butcher D, Lippens JL, Miksovska J, Chapagain PP, Fabris D, Ridgeway ME, Park MA, Fernandez-Lima F.

Phys Chem Chem Phys. 2016 Sep 29;18(38):26691-26702.

 

Molecular insight of DREAM and presenilin 1 C-terminal fragment interactions.

Pham K, Miksovska J.

FEBS Lett. 2016 Apr;590(8):1114-22. doi: 10.1002/1873-3468.12156.

 

Characterization of the Photophysical, Thermodynamic, and Structural Properties of the Terbium(III)-DREAM Complex.

Gonzalez WG, Ramos V, Diaz M, Garabedian A, Molano-Arevalo JC, Fernandez-Lima F, Miksovska J.

Biochemistry. 2016 Mar 29;55(12):1873-86. doi: 10.1021/acs.biochem.6b00067.

 

Amphiphilic Residues 29-44 of DREAM N-Termini Mediate Calmodulin:DREAM Complex Formation.

Gonzalez WG, Arango AS, Miksovska J.

Biochemistry. 2015 Jul 21;54(28):4391-403. doi: 10.1021/acs.biochem.5b00251. 

 

Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging.

Zayas J, Annoual M, Das JK, Felty Q, Gonzalez WG, Miksovska J, Sharifai N, Chiba A, Wnuk SF.

Bioconjug Chem. 2015 Aug 19;26(8):1519-32. doi: 10.1021/acs.bioconjchem.5b00300.

 

Site-specific dynamics of amyloid formation and fibrillar configuration of Aβ(1-23) using an unnatural amino acid.

Liu H, Lantz R, Cosme P, Rivera N, Andino C, Gonzalez WG, Terentis AC, Wojcikiewicz EP, Oyola R, Miksovska J, Du D.

Chem Commun (Camb). 2015 Apr 25;51(32):7000-3. doi: 10.1039/c5cc00149h.

 

Kinetic intermediates of holo- and apo-myoglobin studied using HDX-TIMS-MS and molecular dynamic simulations.

Schenk ER, Almeida R, Miksovska J, Ridgeway ME, Park MA, Fernandez-Lima F.

J Am Soc Mass Spectrom. 2015 Apr;26(4):555-63. doi: 10.1007/s13361-014-1067-9.

 

Ca2+ and Mg2+ modulate conformational dynamics and stability of downstream regulatory element antagonist modulator.

Pham K, Dhulipala G, Gonzalez WG, Gerstman BS, Regmi C, Chapagain PP, Miksovska J.

Protein Sci. 2015 May;24(5):741-51. doi: 10.1002/pro.2646.

 

Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806.

Gonzalez WG, Pham K, Miksovska J.

J Biol Chem. 2014 Nov 14;289(46):32201-13. doi: 10.1074/jbc.M114.577528.

 

Flavin adenine dinucleotide structural motifs: from solution to gas phase.

Molano-Arevalo JC, Hernandez DR, Gonzalez WG, Miksovska J, Ridgeway ME, Park MA, Fernandez-Lima F.

Anal Chem. 2014 Oct 21;86(20):10223-30. doi: 10.1021/ac5023666.

 

Quantitative study of protein-protein interactions by quartz nanopipettes.

Tiwari PB, Astudillo L, Miksovska J, Wang X, Li W, Darici Y, He J.

Nanoscale. 2014 Sep 7;6(17):10255-63. doi: 10.1039/c4nr02964j.

 

Application of ANS fluorescent probes to identify hydrophobic sites on the surface of DREAM.

Gonzalez WG, Miksovska J.

Biochim Biophys Acta. 2014 Sep;1844(9):1472-80. doi: 10.1016/j.bbapap.2014.05.004.

 

Emission tuning of fluorescent kinase inhibitors: conjugation length and substituent effects.

Dhuguru J, Liu W, Gonzalez WG, Babinchak WM, Miksovska J, Landgraf R, Wilson JN.

J Org Chem. 2014 Jun 6;79(11):4940-7. doi: 10.1021/jo500520x.

 

Submillisecond conformational changes in proteins resolved by photothermal beam deflection.

Gonzalez WG, Miksovska J.

J Vis Exp. 2014 Feb 18;(84):e50969. doi: 10.3791/50969.

 

Reduction of the internal disulfide bond between Cys 38 and 83 switches the ligand migration pathway in cytoglobin.

Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J.

J Inorg Biochem. 2013 Dec;129:23-9. doi: 10.1016/j.jinorgbio.2013.08.006. 

 

Photophysical characterization of a benzo-fused analogue of Brooker's merocyanine: solvent polarity and pH effects.

Adjaye-Mensah E, Gonzalez WG, Miksovska J, Wilson JN.

J Phys Chem A. 2012 Dec 27;116(51):12470-5. doi: 10.1021/jp3106869.

 

Conformational dynamics in human neuroglobin: effect of His64, Val68, and Cys120 on ligand migration.

Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J.

Biochemistry. 2012 Dec 18;51(50):9984-94. doi: 10.1021/bi301016u.

 

Graphene oxide as a quencher for fluorescent assay of amino acids, peptides, and proteins.

Li S, Aphale AN, Macwan IG, Patra PK, Gonzalez WG, Miksovska J, Leblanc RM.

ACS Appl Mater Interfaces. 2012 Dec;4(12):7069-75. doi: 10.1021/am302704a.

 

Emission switching of 4,6-diphenylpyrimidones: solvent and solid state effects.

Adjaye-Mensah E, Gonzalez WG, Bussé DR, Captain B, Miksovska J, Wilson JN.

J Phys Chem A. 2012 Aug 30;116(34):8671-7. doi: 10.1021/jp3036956. Epub 2012 Aug 17.

 

Isolation, characterization and antioxidative activity of C-phycocyanin from Limnothrix sp. strain 37-2-1.

Gantar M, Simović D, Djilas S, Gonzalez WW, Miksovska J.

J Biotechnol. 2012 May 31;159(1-2):21-6. doi: 10.1016/j.jbiotec.2012.02.004.

 

Ground- and excited-state properties of Zn(II) tetrakis(4-tetramethylpyridyl) pophyrin specifically encapsulated within a Zn(II) HKUST metal-organic framework.

Larsen RW, Miksovska J, Musselman RL, Wojtas L.

J Phys Chem A. 2011 Oct 27;115(42):11519-24. doi: 10.1021/jp2064408.

 

Time resolved thermodynamics associated with ligand photorelease in heme peroxidases and globins: Open access channels versus gated ligand release.

Vetromile CM, Miksovska J, Larsen RW.

Biochim Biophys Acta. 2011 Aug;1814(8):1065-76. doi: 10.1016/j.bbapap.2011.01.009. 

 

Probing the role of the internal disulfide bond in regulating conformational dynamics in neuroglobin.

Astudillo L, Bernad S, Derrien V, Sebban P, Miksovska J.

Biophys J. 2010 Jul 21;99(2):L16-8. doi: 10.1016/j.bpj.2010.04.033

 

Thermodynamic profile for urea photo-release from a N-(2-nitrobenzyl) caged urea compound.

Dhulipala G, Rubio M, Michael K, Miksovská J.

Photochem Photobiol Sci. 2009 Aug;8(8):1157-63. doi: 10.1039/b900593e.

 

Photothermal studies of CO photodissociation from peroxidases from horseradish and soybean.

Mokdad A, Miksovská J, Larsen RW.

Biochim Biophys Acta. 2009 Nov;1794(11):1558-65. doi: 10.1016/j.bbapap.2009.06.021. 

 

Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain.

Jasuja R, Ulloor J, Yengo CM, Choong K, Istomin AY, Livesay DR, Jacobs DJ, Swerdloff RS, Miksovská J, Larsen RW, Bhasin S.

Mol Endocrinol. 2009 Aug;23(8):1231-41. doi: 10.1210/me.2008-0304.

 

Conformational dynamics associated with photodissociation of CO from dehaloperoxidase studied using photoacoustic calorimetry.

Miksovská J, Horsa S, Davis MF, Franzen S.

Biochemistry. 2008 Nov 4;47(44):11510-7. doi: 10.1021/bi8012033.

 

The contribution of heme propionate groups to the conformational dynamics associated with CO photodissociation from horse heart myoglobin.

Belogortseva N, Rubio M, Terrell W, Miksovská J.

J Inorg Biochem. 2007 Jul;101(7):977-86.

 

Characterization of carbon monoxide photodissociation from Fe(II)LPO with photoacoustic calorimetry.

Lockney D, Miksovská J.

J Phys Chem B. 2006 Nov 30;110(47):24165-70.

 

Thermodynamics of carbon monoxide photodissociation from the fully reduced cytochrome aa3 oxidase from Rb. sphaeroides.

Miksovska J, Gennis RB, Larsen RW.

Biochim Biophys Acta. 2006 Mar;1757(3):182-8. 

 

Spectroscopic and photothermal study of myoglobin conformational changes in the presence of sodium dodecyl sulfate.

Miksovská J, Yom J, Diamond B, Larsen RW.

Biomacromolecules. 2006 Feb;7(2):476-82.

 

Effects of turn stability on the kinetics of refolding of a hairpin in a beta-sheet.

Kuo NN, Huang JJ, Miksovska J, Chen RP, Larsen RW, Chan SI.

J Am Chem Soc. 2005 Dec 7;127(48):16945-54.

 

Characterization of conformational changes coupled to ligand photodissociation from the heme binding domain of FixL.

Miksovská J, Suquet C, Satterlee JD, Larsen RW.

Biochemistry. 2005 Aug 2;44(30):10028-36.

 

Photothermal studies of CO photodissociation from mixed valence Escherichia coli cytochrome bo3.

Miksovská J, Gennis RB, Larsen RW.

FEBS Lett. 2005 Jun 6;579(14):3014-8.

 

Thermodynamic profiles for CO photodissociation from heme model compounds: effect of proximal ligands.

Miksovská J, Norstrom J, Larsen RW.

Inorg Chem. 2005 Feb 21;44(4):1006-14.

 

Time-resolved photoacoustics study of the ruthenium(II) bis(2,2'-bipyridine)(4,4'-dicarboxy-2,2'-bipyridine) complex.

Miksovská J, Larsen RW.

Inorg Chem. 2004 Jun 28;43(13):4051-5

 

Photothermal studies of pH induced unfolding of apomyoglobin.

Miksovská J, Larsen RW.

J Protein Chem. 2003 May;22(4):387-94.

 

Volume and enthalpy profiles of CO rebinding to horse heart myoglobin.

Miksovská J, Day JH, Larsen RW.

J Biol Inorg Chem. 2003 Jul;8(6):621-5.

 

Structure-function relationships in metalloproteins.

Miksovská J, Larsen RW.

Methods Enzymol. 2003;360:302-29

doi: 10.1039/c9mt00059c. [Epub ahead of print]J Org Chem. 2019 Mar 15;84(6):3624-3631